Buy 5-Meo-DMT in UK
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5-MeO-DMT, also known as 5-methoxy-N, N-dimethyltryptamine, as well as O-methylbufotenin or mebufotenin, is an atypical psychedelic drug, entheogen, and alkaloid of the tryptamine and 5-methoxytryptamine families. It is found naturally in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado River toad (Incilius alvarius, formerly Bufo alvarius). It may occur naturally in humans as well.
Like its close relatives, dimethyltryptamine (DMT) and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include five-methoxy, the power, bufo, and toad venom.
The drug has been described as the most powerful psychedelic and, by journalist Michael Pollan, as the “Mount Everest of psychedelics”.
Adverse effects of 5-MeO-DMT include sickness, vomiting, headache, chest pressure, fatigue, anxiety, fear, terror, confusion, paranoia, crying, loss of awareness and motor control, and reactivations The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT1A and 5-HT2A receptors, among others.
However, 5-MeO-DMT differs from most other serotonergic psychedelics in having much greater activity at the serotonin 5-HT1A receptor in addition to the serotonin 5-HT2A receptor.
In relation to this, 5-MeO-DMT has been described as an “atypical” psychedelic and as producing subjective effects notably distinct from those of DMT and other psychedelics, for instance having a relative lack of visual effects.
Nonetheless, 5-MeO-DMT reliably produces mystical experiences in most people who take it.
Use and effects 5-MeO-DMT
5-MeO-DMT is used as a recreational drug and as an entheogen. It is not orally active, requiring a parenteral route such as smoking to produce effects. Other non-oral routes such as intravenous injection, intramuscular injection, rectal administration, sublingual administration, or intranasal administration have also less commonly been used.
In addition to non-oral administration, 5-MeO-DMT can be combined with a monoamine oxidase inhibitor (MAOI) such as the reversible inhibitor of monoamine oxidase A (RIMA) harmaline to allow for oral activity and a much longer duration than it would have otherwise.
However, combination of 5-MeO-DMT with MAOIs can also result in accidental overdose, including instances of serotonin syndrome and death.
Overdose of 5-MeO-DM
There have been cases of death with 5-MeO-DMT. The estimated lethal dose of 5-MeO-DMT relative to a typical recreational dose in humans is unknown.
The median lethal dose (LD50) in animals varies widely, ranging from 1 to 5 mg/kg i.v. in sheep to 48 mg/kg i.v. in mice. In one case, combination of 5-MeO-DMT with harmala alkaloids, which act as monoamine oxidase inhibitors (MAOIs), as well as with other drugs, resulted in death.
However, the exact contribution of 5-MeO-DMT in this case is difficult to determine.
Interactions
5-MeO-DMT can be strongly potentiated by combination with monoamine oxidase inhibitors (MAOIs). In addition, it can become orally active with an extended duration in combination with MAOIs. These interactions have the potential to result in serious toxicity and death.
Absorption
5-MeO-DMT is not orally active and must be administered parenterally.
Distribution of 5-MeO-DMT
5-MeO-DMT is lipophilic and is thought to easily cross the blood–brain barrier. Accordingly, 5-MeO-DMT readily accumulates in the brain in animals with levels higher than in blood.This is in notable contrast to bufotenin (5-HO-DMT or N,N-dimethylserotonin) and serotonin (5-HT), which are hydrophilic and have varying degrees of peripheral selectivity.
What does 5-MeO-DMT do to your brain?
We find that 5-MeO-DMT radically reorganizes low-frequency flows, causing them to become heterogeneous, viscous, and nonrecurring and to cease their travel forward and backward across the cortex.
What is the strongest DMT?
5-MeO-DMT has been described as the most powerful psychedelic and by Michael Pollan as the “Mount Everest of psychedelics”. The phenomenology of 5-MeO-DMT given intransally has been formally clinically studied in a phase 1 clinical trial more recently.
How long does a 5-MeO-DMT trip last?
D., a postdoctoral research fellow in the Behavioral Research Unit, at the Johns Hopkins University School of Medicine. “Because 5-MeO-DMT is short-acting and lasts approximately 30-90 minutes, it could be much easier to use as an adjunct to therapy because current therapies usually involve a 60 – 90 minute session.